Dipartimento di Scienze Cliniche e Biologiche

Prodotti della ricerca selezionati

El Soury M, Gambarotta G. (2019) Soluble neuregulin-1 (NRG1): a factor promoting peripheral nerve regeneration by affecting Schwann cell activity immediately after injury. Neural regeneration research 14(8) 1374-1375 [DOI  PMID]

Crosio A, Fornasari BE, Gambarotta G, Geuna S, Raimondo S, Battiston B, Tos P, Ronchi G. (2019) Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects. Neural regeneration research 14(6) 1079-1084 [DOI  PMID]

Ronchi G, Fornasari BE, Crosio A, Budau CA, Tos P, Perroteau I, Battiston B, Geuna S, Raimondo S, Gambarotta G. (2018) Chitosan Tubes Enriched with Fresh Skeletal Muscle Fibers for Primary Nerve Repair. BioMed research international 2018 9175248 [DOI  PMID]

El Soury M, Fornasari BE, Morano M, Grazio E, Ronchi G, Incarnato D, Giacobini M, Geuna S, Provero P, Gambarotta G. (2018) Soluble Neuregulin1 Down-Regulates Myelination Genes in Schwann Cells. Frontiers in molecular neuroscience 11 157 [DOI  PMID]

Gnavi S, Morano M, Fornasari BE, Riccobono C, Tonda-Turo C, Zanetti M, Ciardelli G, Gambarotta G, Perroteau I, Geuna S, Raimondo S. (2018) Combined Influence of Gelatin Fibre Topography and Growth Factors on Cultured Dorsal Root Ganglia Neurons. Anatomical record (Hoboken, N.J. : 2007) 301(10) 1668-1677 [DOI  PMID]

Morano M, Ronchi G, Nicolo V, Fornasari BE, Crosio A, Perroteau I, Geuna S, Gambarotta G, Raimondo S. (2018) Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervation. Scientific reports 8(1) 5047 [DOI  PMID]

Malloul H, Bennis M, Bonzano S, Gambarotta G, Perroteau I, De Marchis S, Ba-M'hamed S. (2018) Decreased Hippocampal Neuroplasticity and Behavioral Impairment in an Animal Model of Inhalant Abuse. Frontiers in neuroscience 12 35 [DOI  PMID]

Fornasari BE, Ronchi G, Pascal D, Visigalli D, Capodivento G, Nobbio L, Perroteau I, Schenone A, Geuna S, Gambarotta G. (2018) Soluble Neuregulin1 is strongly up-regulated in the rat model of Charcot-Marie-Tooth 1A disease. Experimental biology and medicine (Maywood, N.J.) 243(4) 370-374 [DOI  PMID]

Morano M, Angotti C, Tullio F, Gambarotta G, Penna C, Pagliaro P, Geuna S. (2017) Myocardial ischemia/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress. International journal of cardiology 233 73-79 [DOI  PMID]

Ronchi G, Cillino M, Gambarotta G, Fornasari BE, Raimondo S, Pugliese P, Tos P, Cordova A, Moschella F, Geuna S. (2017) Irreversible changes occurring in long-term denervated Schwann cells affect delayed nerve repair. Journal of neurosurgery 127(4) 843-856 [DOI  PMID]

Fornasari BE, El Soury M, De Marchis S, Perroteau I, Geuna S, Gambarotta G. (2016) Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4. Molecular and cellular neurosciences 77 87-94 [DOI  PMID]

Baravalle R, Valetti F, Catucci G, Gambarotta G, Chiesa M, Maurelli S, Giamello E, Barone I, Catalano S, Ando S, Di Nardo G, Gilardi G. (2017) Effect of sildenafil on human aromatase activity: From in vitro structural analysis to catalysis and inhibition in cells. The Journal of steroid biochemistry and molecular biology 165(Pt B) 438-447 [DOI  PMID]

Ronchi G, Raimondo S, Geuna S, Gambarotta G. (2015) New insights on the standardization of peripheral nerve regeneration quantitative analysis. Neural regeneration research 10(5) 707-9 [DOI  PMID]

Ronchi G, Haastert-Talini K, Fornasari BE, Perroteau I, Geuna S, Gambarotta G. (2016) The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration. The European journal of neuroscience 43(3) 351-64 [DOI  PMID]

Gambarotta G, Pascal D, Ronchi G, Morano M, Jager SB, Moimas S, Zentilin L, Giacca M, Perroteau I, Tos P, Geuna S, Raimondo S. (2015) Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation. Gene therapy 22(11) 901-7 [DOI  PMID]

Minieri V, Saviozzi S, Gambarotta G, Lo Iacono M, Accomasso L, Cibrario Rocchietti E, Gallina C, Turinetto V, Giachino C. (2015) Persistent DNA damage-induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells. Journal of cellular and molecular medicine 19(4) 734-43 [DOI  PMID]

Gambarotta G, Ronchi G, Geuna S, Perroteau I. (2014) Neuregulin 1 isoforms could be an effective therapeutic candidate to promote peripheral nerve regeneration. Neural regeneration research 9(12) 1183-5 [DOI  PMID]

Pascal D, Giovannelli A, Gnavi S, Hoyng SA, de Winter F, Morano M, Fregnan F, Dell'Albani P, Zaccheo D, Perroteau I, Pellitteri R, Gambarotta G. (2014) Characterization of glial cell models and in vitro manipulation of the neuregulin1/ErbB system. BioMed research international 2014 310215 [DOI  PMID]

Gambarotta G, Ronchi G, Friard O, Galletta P, Perroteau I, Geuna S. (2014) Identification and validation of suitable housekeeping genes for normalizing quantitative real-time PCR assays in injured peripheral nerves. PloS one 9(8) e105601 [DOI  PMID]

Gnavi S, di Blasio L, Tonda-Turo C, Mancardi A, Primo L, Ciardelli G, Gambarotta G, Geuna S, Perroteau I. (2017) Gelatin-based hydrogel for vascular endothelial growth factor release in peripheral nerve tissue engineering. Journal of tissue engineering and regenerative medicine 11(2) 459-470 [DOI  PMID]

Tonda-Turo C, Gnavi S, Ruini F, Gambarotta G, Gioffredi E, Chiono V, Perroteau I, Ciardelli G. (2017) Development and characterization of novel agar and gelatin injectable hydrogel as filler for peripheral nerve guidance channels. Journal of tissue engineering and regenerative medicine 11(1) 197-208 [DOI  PMID]

Fregnan F, Gnavi S, Macri L, Perroteau I, Gambarotta G. (2014) The four isoforms of the tyrosine kinase receptor ErbB4 provide neural progenitor cells with an adhesion preference for the transmembrane type III isoform of the ligand neuregulin 1. Neuroreport 25(4) 233-41 [DOI  PMID]

Faroni A, Castelnovo LF, Procacci P, Caffino L, Fumagalli F, Melfi S, Gambarotta G, Bettler B, Wrabetz L, Magnaghi V. (2014) Deletion of GABA-B receptor in Schwann cells regulates remak bundles and small nociceptive C-fibers. Glia 62(4) 548-65 [DOI  PMID]

Gambarotta G, Fregnan F, Gnavi S, Perroteau I. (2013) Neuregulin 1 role in Schwann cell regulation and potential applications to promote peripheral nerve regeneration. International review of neurobiology 108 223-56 [DOI  PMID]

Haastert-Talini K, Geuna S, Dahlin LB, Meyer C, Stenberg L, Freier T, Heimann C, Barwig C, Pinto LF, Raimondo S, Gambarotta G, Samy SR, Sousa N, Salgado AJ, Ratzka A, Wrobel S, Grothe C. (2013) Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects. Biomaterials 34(38) 9886-904 [DOI  PMID]

Ronchi G, Gambarotta G, Di Scipio F, Salamone P, Sprio AE, Cavallo F, Perroteau I, Berta GN, Geuna S. (2013) ErbB2 receptor over-expression improves post-traumatic peripheral nerve regeneration in adult mice. PloS one 8(2) e56282 [DOI  PMID]

Pregno G, Zamburlin P, Gambarotta G, Farcito S, Licheri V, Fregnan F, Perroteau I, Lovisolo D, Bovolin P. (2011) Neuregulin1/ErbB4-induced migration in ST14A striatal progenitors: calcium-dependent mechanisms and modulation by NMDA receptor activation. BMC neuroscience 12 103 [DOI  PMID]

Fregnan F, Petrov V, Garzotto D, De Marchis S, Offenhauser N, Grosso E, Chiorino G, Perroteau I, Gambarotta G. (2011) Eps8 involvement in neuregulin1-ErbB4 mediated migration in the neuronal progenitor cell line ST14A. Experimental cell research 317(6) 757-69 [DOI  PMID]

Audisio C, Raimondo S, Nicolino S, Gambarotta G, Di Scipio F, Macri L, Montarolo F, Giacobini-Robecchi MG, Porporato P, Filigheddu N, Graziani A, Geuna S, Perroteau I. (2009) Morphological and biomolecular characterization of the neonatal olfactory bulb ensheathing cell line. Journal of neuroscience methods 185(1) 89-98 [DOI  PMID]

Nicolino S, Panetto A, Raimondo S, Gambarotta G, Guzzini M, Fornaro M, Battiston B, Tos P, Geuna S, Perroteau I. (2009) Denervation and reinnervation of adult skeletal muscle modulate mRNA expression of neuregulin-1 and ErbB receptors. Microsurgery 29(6) 464-72 [DOI  PMID]

Amado S, Simoes MJ, Armada da Silva PA, Luis AL, Shirosaki Y, Lopes MA, Santos JD, Fregnan F, Gambarotta G, Raimondo S, Fornaro M, Veloso AP, Varejao AS, Mauricio AC, Geuna S. (2008) Use of hybrid chitosan membranes and N1E-115 cells for promoting nerve regeneration in an axonotmesis rat model. Biomaterials 29(33) 4409-19 [DOI  PMID]

Geuna S, Tos P, Raimondo S, Lee JM, Gambarotta G, Nicolino S, Fornaro M, Papalia I, Perroteau I, Battiston B. (2007) Functional, morphological and biomolecular assessment of posttraumatic neuro-muscular recovery in the rat forelimb model. Acta neurochirurgica. Supplement 100 173-7 [PMID]

Geuna S, Nicolino S, Raimondo S, Gambarotta G, Battiston B, Tos P, Perroteau I. (2007) Nerve regeneration along bioengineered scaffolds. Microsurgery 27(5) 429-38 [DOI  PMID]

Bovetti S, De Marchis S, Gambarotta G, Fasolo A, Perroteau I, Puche AC, Bovolin P. (2006) Differential expression of neuregulins and their receptors in the olfactory bulb layers of the developing mouse. Brain research 1077(1) 37-47 [DOI  PMID]

Giampietro C, Luzzati F, Gambarotta G, Giacobini P, Boda E, Fasolo A, Perroteau I. (2005) Stathmin expression modulates migratory properties of GN-11 neurons in vitro. Endocrinology 146(4) 1825-34 [DOI  PMID]

Gambarotta G, Garzotto D, Destro E, Mautino B, Giampietro C, Cutrupi S, Dati C, Cattaneo E, Fasolo A, Perroteau I. (2004) ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1beta1-induced migration. The Journal of biological chemistry 279(47) 48808-16 [DOI  PMID]

Mautino B, Dalla Costa L, Gambarotta G, Perroteau I, Fasolo A, Dati C. (2004) Bioactive recombinant neuregulin-1, -2, and -3 expressed in Escherichia coli. Protein expression and purification 35(1) 25-31 [DOI  PMID]

Medico E, Gentile A, Lo Celso C, Williams TA, Gambarotta G, Trusolino L, Comoglio PM. (2001) Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth. Cancer research 61(15) 5861-8 [PMID]

Medico E, Gambarotta G, Gentile A, Comoglio PM, Soriano P. (2001) A gene trap vector system for identifying transcriptionally responsive genes. Nature biotechnology 19(6) 579-82 [DOI  PMID]

Maggiora P, Gambarotta G, Olivero M, Giordano S, Di Renzo MF, Comoglio PM. (1997) Control of invasive growth by the HGF receptor family. Journal of cellular physiology 173(2) 183-6 [DOI  PMID]

Anastasi S, Giordano S, Sthandier O, Gambarotta G, Maione R, Comoglio P, Amati P. (1997) A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiation. The Journal of cell biology 137(5) 1057-68 [DOI  PMID]

Gambarotta G, Boccaccio C, Giordano S, Ando M, Stella MC, Comoglio PM. (1996) Ets up-regulates MET transcription. Oncogene 13(9) 1911-7 [PMID]

Gambarotta G, Pistoi S, Giordano S, Comoglio PM, Santoro C. (1994) Structure and inducible regulation of the human MET promoter. The Journal of biological chemistry 269(17) 12852-7 [PMID]

Boccaccio C, Gaudino G, Gambarotta G, Galimi F, Comoglio PM. (1994) Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF. The Journal of biological chemistry 269(17) 12846-51 [PMID]

Insegnamenti

• ADVANCED CELL BIOLOGY AND BIOTECHNOLOGY (SVB0040)
  Cellular and Molecular Biology

Temi di ricerca

- peripheral nerve regeneration
- migration of neuronal progenitors in the central nervous system
- the system neuregulin1/ErbB and its role in peripheral nerve regeneration and neuronal progenitor migration

Gruppi di ricerca

• Peripheral nerve regeneration group

Progetti di ricerca

• Strategie per migliorare la rigenerazione di nervi autonomici peri-prostatici

Organi

• Consiglio di Dipartimento - Dipartimento di Scienze Cliniche e Biologiche

• Monitoring and Review Committee

Ricevimento studenti

The teacher meets students upon request (please write to giovanna.gambarotta@unito.it).